A few years ago I got calf Botox about twice, and the effect was immediate. My calves felt stiff when walking and my legs got tired quickly, but they spray a cooling spray before the procedure so it won’t hurt. But it had no effect at all Since I’m fairly tall, my bones are long and large so I tend to have a lot of muscle, but I also have some fat, so they said I should try calf Botox first and get fat-dissolving injections together next time, but Botox alone was fine for me.
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